HRID1160257

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID178418361

未命名化合物

2 次

结构：CC(C)[Si](O[C@H]1CC[C@H](N2CC[C@@H](Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1)(C(C)C)C(C)C

HCID178460990

未命名化合物

PRODUCTS

生成物

结构：CC(C)[Si](O[C@H]1CC[C@H](N2CC[C@@H](Cc3c(Cl)cc(O)cc3Cl)C2=O)CC1)(C(C)C)C(C)C

HCID178460989

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Stir (R)-3-(4-Benzyloxy-2,6-dichloro-benzyl)-trans-1-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-2-one (Preparation 17) (1.83 g, 3.03 mmol) and palladium hydroxide (20% on carbon) (0.200 g, 10% by weight) in 100 ml of Ethyl Acetate. Bubble hydrogen gas through the solution while stirring at room temperature for 5 minutes. Stir the mixture under the hydrogen gas atmosphere for 5 hours. Filter through celite and strip the solvent to receive 1.42 g of the title compound (91%). Mass spectrum (apci) m/z=514 (M+H).

WORKUP

后处理

filtrationFilter through celite and strip the solvent

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a604de1de2aa4e0ea8f1689e9b49fb07
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816349B2
来源说明: uspto-grants-2010_10

反应 SMILES

C([O:8][C:9]1[CH:38]=[C:37]([Cl:39])[C:12]([CH2:13][C@@H:14]2[CH2:18][CH2:17][N:16]([C@H:19]3[CH2:24][CH2:23][C@H:22]([O:25][Si:26]([CH:33]([CH3:35])[CH3:34])([CH:30]([CH3:32])[CH3:31])[CH:27]([CH3:29])[CH3:28])[CH2:21][CH2:20]3)[C:15]2=[O:36])=[C:11]([Cl:40])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[OH-].[Pd+2].[OH-]>[Cl:39][C:37]1[CH:38]=[C:9]([OH:8])[CH:10]=[C:11]([Cl:40])[C:12]=1[CH2:13][C@@H:14]1[CH2:18][CH2:17][N:16]([C@H:19]2[CH2:20][CH2:21][C@H:22]([O:25][Si:26]([CH:27]([CH3:28])[CH3:29])([CH:33]([CH3:34])[CH3:35])[CH:30]([CH3:31])[CH3:32])[CH2:23][CH2:24]2)[C:15]1=[O:36]