反应详情

温度

50 °C

A mixture of N-benzyloxycarbonylguanidine 1.93 g (10 mmol), triethylamine 1.39 ml (10 mmol), chloroacetone 2.40 ml (30 mmol) and ethyl acetate 40 ml was stirred at 50° C. for 10 hours. The reaction solution was washed with water and an aqueous sodium chloride solution and dried on magnesium sulfate. After evaporation of the solvent, the residue was purified by a column chromatography on silica gel and further recrystallized from n-hexane to give 500 mg of the title compound (yield: 22%).

1. washThe reaction solution was washed with water
2. dry with materialan aqueous sodium chloride solution and dried on magnesium sulfate
3. customAfter evaporation of the solvent
4. customthe residue was purified by a column chromatography on silica gel
5. customfurther recrystallized from n-hexane