N-Methylcyclohexylamine → HCID 11739881, compound

HRID 1160532Notes

Reaction equation

HRID 1160532 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][CH2:14][CH3:15])=[C:11]([C:16](Cl)=[O:17])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:19][NH:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][CH2:14][CH3:15])=[C:11]([C:16]([N:20]([CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH3:19])=[O:17])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7514N-MethylcyclohexylamineHCID 27775851-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE

Product 1

HCID 11739881HCID 11739881, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a suspension of 1-(4-chlorophenyl)-5-propyl-pyrazole-4-carbonyl chloride (commercially available, 302 mg, 1.07 mmol) in DCM (5 ml) was added 1 drop of DMF followed by N-methylcyclohexylamine (349 μL, 2.68 mmol). The reaction mixture was stiffed at room temperature for two hours then stopped.

Sources & evidence

ORD record
ord-6db79471ccfc40f6a761b5afc1430ec3
Source dataset
uspto-grants-2010_10
Patent number
US07816391B2

Reaction notes

Loading…