HCID 67153507, compound → HCID 135706016, compound

HRID 1160862Notes

Reaction equation

HRID 1160862 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][N:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.C1COCC1.[Pd]>[F:24][C:21]([F:22])([F:23])[C:18]1[CH:19]=[CH:20][C:15]([C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)=[N:16][CH:17]=1

Participants

6

Reactant 2

HCID 67153507HCID 67153507, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 135706016HCID 135706016, compoundYield 67.5%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(4-Benzyloxy-phenyl)-5-trifluoromethyl-pyridine (2.55 g) in ethanol (100 mL) and THF (25 mL) is added Pd/C (5%, 0.253 g), the mixture is stirred under 60 psi of hydrogen overnight. The catalyst is filtered off, concentration of the filtrate gave the title compound (1.25 g, 67.5%).

Workup

  1. filtrationThe catalyst is filtered off

Sources & evidence

ORD record
ord-3c15e21724e945d4be4c852838be4053
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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