反应详情

温度

20 °C

A solution of 2-[(4-acetylphenyl)amino]-1-[2-(1,3-dioxolan-2-yl)ethyl]-N,N-bis(3-methylbutyl)-1H-benzimidazole-6-carboxamide (900 mg) in a mixture of tetrahydrofuran (30 ml) and aqueous hydrochloric acid (3N, 40 ml) is stirred for 18 hours at a temperature of approximately 20° C. then concentrated under reduced pressure at 40° C. Dichloromethane (100 ml) is added to the remaining aqueous phase. After decantation and extractions, the combined organic phases are washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40° C. in order to produce the expected compound in the form of a beige foam (820 mg, 99% yield).

1. concentrationthen concentrated under reduced pressure at 40° C
2. additionDichloromethane (100 ml) is added to the remaining aqueous phase
3. extractionAfter decantation and extractions
4. washthe combined organic phases are washed with salt water
5. dry with materialdried over Na2SO4
6. concentrationthen concentrated under reduced pressure at 40° C. in order