Hydrochloric Acid → (R)-3-Methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoic acid

HRID 1161241Notes

Reaction equation

HRID 1161241 reaction equation
[CH3:1][CH:2]([CH3:22])[C@@H:3]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[N+:18]([O-:20])=[O:19])[C:9]1=[O:21])[C:4]([O:6]C)=[O:5].[OH-].[Li+].C(O)(C)(C)C.O.Cl>>[CH3:1][CH:2]([CH3:22])[C@@H:3]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[N+:18]([O-:20])=[O:19])[C:9]1=[O:21])[C:4]([OH:6])=[O:5]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 6386tert-ButanolHCID 59515729(R)-Methyl 3-methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoate

Product 1

HCID 59515700(R)-3-Methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoic acid

Procedure

(R)-Methyl 3-methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoate (0.6 g, 0.002 mol) was stirred with lithium hydroxide (0.09 g, 0.004 mol) in tert-butyl alcohol (4 mL, 0.04 mol) and water (2 mL, 0.1 mol) at 0° C. for 3 hours. 1 N HCl was added until pH<7 and then reaction mixture was extracted with CH2Cl2 (40 mL×3). The organic layers were dried over MgSO4, filtered, purified via flash chromatography (12 g of silica gel, 0-50% EtOAc/Hexane) and the product was recovered as a yellow oil. MS m/z 291.0 (M+H)+.

Workup

  1. customreaction mixture
  2. extractionwas extracted with CH2Cl2 (40 mL×3)
  3. dry with materialThe organic layers were dried over MgSO4
  4. filtrationfiltered
  5. custompurified via flash chromatography (12 g of silica gel, 0-50% EtOAc/Hexane)
  6. customthe product was recovered as a yellow oil

Sources & evidence

ORD record
ord-522ba0302c9c491b95c1ceb252e5a6b4
Source dataset
uspto-grants-2010_10
Patent number
US07816371B2

Reaction notes

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