Ethyl Acetate → HCID 59515870, compound

HRID 1161247Notes

Reaction equation

HRID 1161247 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:20])[C:16]([O:18]C)=[O:17])[C:9]2=[O:14])([O-:3])=[O:2].[I-].[Li+].C(OCC)(=O)C>>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:20])[C:16]([OH:18])=[O:17])[C:9]2=[O:14])([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 66321Lithium iodideHCID 59515826HCID 59515826, compound

Product 1

HCID 59515870HCID 59515870, compound

Procedure

(R)-Methyl 2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanoate (5.2 g, 0.019 mol) and lithium iodide (10 g, 0.08 mol) were refluxed in ethyl acetate (200 mL, 2 mol) for 64 hours. The solid was filtered, and the filtrate was concentrated and gave a brown solid.

Workup

  1. filtrationThe solid was filtered
  2. concentrationthe filtrate was concentrated
  3. customgave a brown solid

Sources & evidence

ORD record
ord-f527dcbb4722478a887d9974643ff076
Source dataset
uspto-grants-2010_10
Patent number
US07816371B2

Reaction notes

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