Trifluoroacetic acid → HCID 44198604, compound

HRID 1161338Notes

Reaction equation

HRID 1161338 reaction equation
C([O:5][C:6](=[O:44])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:42])[CH:17]([N:24]2[C:28]3[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:27]=3[N:26]=[C:25]2[C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=2)[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:11]([F:43])[CH:10]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:41][C:38]1[CH:39]=[CH:40][C:35]([C:25]2[N:24]([CH:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:16]([NH:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:44])=[O:5])=[CH:10][C:11]=3[F:43])=[O:42])[C:28]3[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:27]=3[N:26]=2)=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68645259HCID 68645259, compound

Product 1

HCID 44198604HCID 44198604, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-acetic acid tert-butyl ester (120 mg, 0.19 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (1.5 ml). After 2 h, the solvent was removed under reduced pressure. The resulting oil (78 mg, 71%) solidified upon standing in the refrigerator.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ac606d1b26b74f60ad42cace6929c9f0
Source dataset
uspto-grants-2010_10
Patent number
US07816540B2

Reaction notes

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