tert-Butanol → HCID 136173745, compound

HRID 1161500Notes

Reaction equation

HRID 1161500 reaction equation
[CH3:1][N:2]([CH3:45])[C:3]([CH2:5][O:6][C:7]1[C:8]([F:44])=[C:9]([CH:15]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]3[N:42]=[C:41]([CH3:43])[O:40][N:39]=3)=[CH:34][CH:33]=2)[C:16]2[NH:20][C:19](=[O:21])[N:18]([C:22]3[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=3C(O)=O)[N:17]=2)[CH:10]=[C:11]([CH2:13][CH3:14])[CH:12]=1)=[O:4].C([N:48]([CH2:51]C)CC)C.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:60])C=CC=CC=1.C(OCC)(=O)C.[C:76]([OH:80])([CH3:79])([CH3:78])[CH3:77]>O>[C:76]([O:80][C:51](=[O:60])[NH:48][C:23]1[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=1[N:18]1[C:19](=[O:21])[NH:20][C:16]([CH:15]([C:9]2[CH:10]=[C:11]([CH2:13][CH3:14])[CH:12]=[C:7]([O:6][CH2:5][C:3](=[O:4])[N:2]([CH3:45])[CH3:1])[C:8]=2[F:44])[NH:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]3[N:42]=[C:41]([CH3:43])[O:40][N:39]=3)=[CH:34][CH:33]=2)=[N:17]1)([CH3:79])([CH3:78])[CH3:77]

Participants

7

Reactant 5

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 199401P,P-Diphenylphosphinic azideHCID 136173790HCID 136173790, compound

Product 1

HCID 136173745HCID 136173745, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.320 g of 2-(3-{(3-dimethylcarbamoylmethoxy-5-ethyl-2-fluorophenyl)-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]methyl}-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl)benzoic acid, 0.098 ml of triethylamine and 0.151 ml of diphenylphosphorylazide in 10 ml of t-butanol was stirred under a nitrogen atmosphere at room temperature for 20 hours and then at 70° C. for 36 hours. After adding 100 ml of ethyl acetate and 50 ml of water to the reaction mixture, the organic layer was dried over anhydrous magnesium sulfate, the desiccating agent was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (methanol-ethyl acetate) to give the title compound (0.135 g) as a white solid.

Workup

  1. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  2. filtrationthe desiccating agent was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (methanol-ethyl acetate)

Sources & evidence

ORD record
ord-eef720127cbf47498cdd56895f83c473
Source dataset
uspto-grants-2010_10
Patent number
US07816522B2

Reaction notes

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