HRID1161527

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID67097302

未命名化合物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(OCCF)c1F

HCID72312758

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cccc(-n2nc(C(Nc3ccc(-c4noc(C)n4)cc3)c3cc(OC)cc(OCCF)c3F)[nH]c2=O)n1

HCID136173631

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 85 °C

PROCEDURE

实验过程

After adding 149 mg of 6-hydrazinopyridine-2-carboxylic acid methyl ester hydrochloride and 92 μl of triethylamine to a solution of 255 mg of {2-[2-fluoro-3-(2-fluoroethoxy)-5-methoxyphenyl]-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester (Example (3e)) in 5 ml of DMF, the mixture was stirred at 85° C. for 24 hours under a nitrogen atmosphere.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f17a2313ac641eb8842869c4bbb9b7c
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816522B2
来源说明: uspto-grants-2010_10

反应 SMILES

Cl.[CH3:2][O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][NH2:13])[N:7]=1)=[O:5].C(N(CC)CC)C.C[O:22][C:23](=O)[N:24]=[C:25](SC)[C:26]([C:40]1[CH:45]=[C:44]([O:46][CH3:47])[CH:43]=[C:42]([O:48][CH2:49][CH2:50][F:51])[C:41]=1[F:52])=[N:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]2[N:38]=[C:37]([CH3:39])[O:36][N:35]=2)=[CH:30][CH:29]=1>CN(C=O)C>[CH3:2][O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[C:23](=[O:22])[NH:24][C:25]([CH:26]([C:40]3[CH:45]=[C:44]([O:46][CH3:47])[CH:43]=[C:42]([O:48][CH2:49][CH2:50][F:51])[C:41]=3[F:52])[NH:27][C:28]3[CH:29]=[CH:30][C:31]([C:34]4[N:38]=[C:37]([CH3:39])[O:36][N:35]=4)=[CH:32][CH:33]=3)=[N:13]2)[N:7]=1)=[O:5]