反应详情

温度

60 °C

After adding 55 mg of 4-hydrazinothiazole-5-carboxylic acid methyl ester (Example (162c)) and 300 μl of triethylamine to a solution of 160 mg of {2-(9-methoxy-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester (Example 30c) in 5 ml of THF, the mixture was stirred overnight at 60° C. under a nitrogen atmosphere. The reaction mixture was then concentrated. The residue was dissolved in 5 ml of DMF, and then 0.3 ml of triethylamine was added and the mixture was stirred at 80° C. for 6 hours.

1. concentrationThe reaction mixture was then concentrated
2. dissolutionThe residue was dissolved in 5 ml of DMF
3. addition0.3 ml of triethylamine was added
4. stirringthe mixture was stirred at 80° C. for 6 hours