Ethane, 1-fluoro-2-iodo- → 2-Fluoro-5-methoxy-3-(2-methoxyethoxy)benzaldehyde
Reaction equation
[F:1][C:2]1[C:9]([OH:10])=[CH:8][C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]=[O:5].Br[CH2:14][CH2:15][O:16][CH3:17].COC(=O)N=C(SC)C(C1C=C(OC)C=C(O)C=1F)=NC1C=CC(C2N=C(C)ON=2)=CC=1.FCCI>>[F:1][C:2]1[C:9]([O:10][CH2:14][CH2:15][O:16][CH3:17])=[CH:8][C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]=[O:5]Participants
5
Reactant 4
Product 1
Procedure
The same procedure was carried out as in Example (3e), except that 2-25 fluoro-3-hydroxy-5-methoxybenzaldehyde [CAS No. 883576-31-6] and 2-bromoethylmethyl ether were used instead of respectively [2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester and 1-fluoro-2-iodoethane, to give the title compound was obtained as a white solid.
Sources & evidence
- ORD record
- ord-ee2a85b6d5314de9aaf8ae2b6222903d
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07816522B2
Reaction notes
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