反应详情

A mixture of 2-aminobenzonitrile (0.01 mole), 2,5-dimethoxytetrahydrofuran (0.01 mole) and glacial acetic acid (10 ml) was heated under reflux for 30 minutes (TLC check). The acetic acid and ethyl acetate formed was evaporated off and the residue was purified using flash chromatography on silica gel (eluent: CH2Cl2). The pure fraction was recrystallized from the appropriate solvent (mostly ethanol).

1. temperaturewas heated
2. temperatureunder reflux for 30 minutes (TLC check)
3. customwas evaporated off
4. customthe residue was purified
5. customThe pure fraction was recrystallized from the appropriate solvent (mostly ethanol)