Methylamine → HCID 68647627, compound

HRID 1161660Notes

Reaction equation

HRID 1161660 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([S:14][CH2:15][CH3:16])[N:3]=1.[CH3:17][NH2:18]>CO>[CH2:15]([S:14][C:4]1[N:3]=[C:2]([CH2:17][NH2:18])[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 16642953HCID 16642953, compound

Product 1

HCID 68647627HCID 68647627, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of compound 4-chloro-2-ethylsulfanyl-6-phenyl-pyrimidine (1 g, 4 mmol) and aqueous methylamine (0.74 g, 24 mmol) in methanol (20 mL) was stirred at refluxing temperature for 16 hours under nitrogen atmosphere. The reaction mixture was then cooled to temperature in the range of 20-40° C. The solid separated was filtered off and dried under reduced pressure. It was finally titrated with petroleum-ether to afford the title compound as an off white solid.

Workup

  1. temperatureat refluxing temperature for 16 hours under nitrogen atmosphere
  2. customThe solid separated
  3. filtrationwas filtered off
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-87a0b3195fa94247b17133db8a3e64ba
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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