Phenylboronic Acid → 1-(2,6-Diphenyl-pyrimidin-4-yl)-piperidin-4-ol

HRID 1161673Notes

Reaction equation

HRID 1161673 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([C:2]2[N:7]=[C:6]([N:8]3[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]3)[CH:5]=[C:4]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:3]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 586260781-(2-Chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol

Product 1

HCID 586260971-(2,6-Diphenyl-pyrimidin-4-yl)-piperidin-4-olYield 61%

Procedure

1-(2,6-Diphenyl-pyrimidin-4-yl)-piperidin-4-ol was prepared from compound 1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol and phenyl boronic acid by a procedure analogous to that disclosed in Examples 39 and 95, as described above. Yield: 61%.

Sources & evidence

ORD record
ord-f7e6d965f6c645a2bdc12830ade7f10f
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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