Piperidin-4-ol → HCID 58626140, compound

HRID 1161709Notes

Reaction equation

HRID 1161709 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=2)[CH:3]=1.[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>C(O)CCC>[CH3:24][S:21]([C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:4]2[N:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:7]=[C:2]([N:29]3[CH2:30][CH2:31][CH:26]([OH:25])[CH2:27][CH2:28]3)[CH:3]=2)=[CH:16][CH:17]=1)(=[O:23])=[O:22]

Participants

4

Reactant 2

HCID 79341Piperidin-4-olHCID 58626100HCID 58626100, compound

Product 1

HCID 58626140HCID 58626140, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The (6-chloro-2-phenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine (0.18 g, 0.48 mmol) was treated with 4-hydroxy piperidine (0.097 g, 0.97 mmol) in n-butanol at refluxing temperature for 12 hour to give the desired product.

Workup

  1. temperatureat refluxing temperature for 12 hour

Sources & evidence

ORD record
ord-7e535f392d164d9ba33c615322234efd
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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