Triethylamine → HCID 58626077, compound

HRID 1161713Notes

Reaction equation

HRID 1161713 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.[F:10][C:11]([F:21])([F:20])[O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1.C(N(CC)CC)C>C(Cl)(Cl)Cl.CCCCCC>[Cl:9][C:4]1[CH:5]=[C:6]([Cl:8])[N:7]=[C:2]([NH:17][C:16]2[CH:18]=[CH:19][C:13]([O:12][C:11]([F:10])([F:20])[F:21])=[CH:14][CH:15]=2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 773782,4,6-TrichloropyrimidineHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 58626077HCID 58626077, compound

Reagents, catalysts & solvents 1

HCID 21585165Chloroform hexaneSolvent

Procedure

The title compound was prepared by reacting 2,4,6-trichloro pyrimidine (2 g, 10 mmol) with 4-trifluoromethoxy aniline (1.94 g, 10 mmol) in presence of triethylamine (5.5 g, 50 mmol) in a solvent chloroform: hexane (1:1, 20 mL) at reflux temperature for 7 hours.

Workup

  1. temperatureat reflux temperature for 7 hours

Sources & evidence

ORD record
ord-85f973c2e907434188d3267a987b1834
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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