反应详情

2-Amino-4-chloro-6-(2,4-dimethylphenyl)-pyrimidine-5-carbaldehyde was added to a suspension of sodium sulphide (5 eq.) in DMF and the mixture stirred for ˜60 mins, to give a yellow suspension. The suspension was poured into water, and the solution filtered. The filtrate was acidified with acetic acid, to give a yellow precipitate. The solids were removed by filtration and washed with water and hexane, dried in vacuo, to give a yellow powder.

1. customto give a yellow suspension
2. filtrationthe solution filtered
3. customto give a yellow precipitate
4. customThe solids were removed by filtration
5. washwashed with water and hexane
6. customdried in vacuo
7. customto give a yellow powder