Triethylamine → HCID 86609163, compound

HRID 1161922Notes

Reaction equation

HRID 1161922 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][C@@H:14]([F:16])[CH2:13][C@H:12]1[C:17]#[N:18])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl.[NH2:27][OH:28]>C(O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:15][C@@H:14]([F:16])[CH2:13][C@H:12]1[C:17]([NH2:18])=[N:27][OH:28])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 23626152Benzyl (2S,4S)-2-cyano-4-fluoropyrrolidine-1-carboxylate

Product 1

HCID 86609163HCID 86609163, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Benzyl-(2S,4S)-2-cyano-4-fluoropyrrolidine-1-carboxylate dissolved in absolute ethanol was treated with triethyl amine (1.5 eq.) and hydroxylamine hydrochloride (1.3 eq.).

Sources & evidence

ORD record
ord-891a6d224c4647b294c98cd8c57f64f8
Source dataset
uspto-grants-2010_10
Patent number
US07820660B2

Reaction notes

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