Cesium carbonate → HCID 66892777, compound

HRID 1162010Notes

Reaction equation

I[C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[NH:14]1[CH2:19][CH2:18][NH:17][CH:16]2[CH2:20][S:21](=[O:24])(=[O:23])[CH2:22][CH:15]12.CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C([O-])([O-])=O.[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C(C)=CC=CC=1>[N+:11]([C:4]1[CH:3]=[C:2]([N:14]2[CH2:19][CH2:18][NH:17][CH:16]3[CH2:20][S:21](=[O:24])(=[O:23])[CH2:22][CH:15]23)[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[CH:5]=1)([O-:13])=[O:12]

Participants

Conditions

Temperature: 120 °C

Procedure

Xylene (150 mL) was added to 7-iodo-5-nitro-1-benzofuran (1.00 g, 3.46 mmol), octahydrothieno[3,4-b]pyrazine 6,6-dioxide (0.73 g, 4.15 mmol; Intermediate 34), Pd2(dba)3 (0.08 g, 0.87 mmol), Xantphos (0.20 g, 0.35 mmol) and Cs2CO3 (1.59 g, 4.84 mmol). The resulting mixture was stirred at 120° C. overnight, filtered through Celite and the solvent was removed in vacuo. The crude product was purified by flash chromatography [eluent: DCM and DCM:MeOH (1:1)] and then recrystallized from MeOH to afford 0.354 g (8%) of the title product. HPLC 90%, RT: 1.390 (System A; 10-97% MeCN over 3 min). 1H NMR (270 MHz, CDCl3) δ ppm 2.85 (dd, J=12.62, 7.42 Hz, 1H) 3.16-3.49 (m, 6H) 3.71 (t, J=11.63 Hz, 1H) 4.02-4.05 (m, 1H) 5.17-5.25 (m, 1H) 6.93 (d, J=2.23 Hz, 1H) 7.62 (t, J=2.72 Hz, 1H) 7.77 (d, J=1.98 Hz, 1H) 8.19 (d, J=1.98 Hz, 1H). LC-MS 338 (M+H)+.

Workup

filtrationfiltered through Celite
customthe solvent was removed in vacuo
customThe crude product was purified by flash chromatography [eluent: DCM and DCM:MeOH (1:1)]
customrecrystallized from MeOH

Sources & evidence

ORD record: ord-eace99707781485f9164ec9b9a328478
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820675B2

Reaction notes

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