HRID1162018
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
To 7-iodo-5-nitro-1-benzofuran (231.4 mg, 0.08 mmol) the following was added: Xantphos (92.6 mg, 0.16 mmol), Pd2 dba3 (36.6 mg, 0.04 mmol), sodium tert-butoxide (215.4 mg, 2.24 mmol), 2-(trifluoromethyl)piperazine (148.1 mg, 0.96 mmol; Intermediate 45) and xylene (23 mL). The resulting mixture was stirred at 100° C. for 3 days. Filtration through Celite and purification by flash chromatography, using EtOAc:heptane (1:1) as eluent, furnished 1-(5-nitro-1-benzofuran-7-yl)-3-(trifluoromethyl)piperazine (112 mg, 44% yield). HPLC 90%, RT=1.648 min (System A; 10-97% MeCN over 3 min), MS (ESI+) m/z 316 (M+H)+.
WORKUP
后处理
- filtrationFiltration
- customthrough Celite and purification by flash chromatography