反应详情

To a suspension of lithium aluminum hydride (5.0 g) in anhydrous THF (150 ml) was added a solution of (4-benzyl-1-piperazinyl)acetonitrile (11 g) obtained in Example 95a) in anhydrous THF (50 ml) under ice-cooling. The reaction solution was refluxed for 3 hours, to the reaction solution was then added sodium sulfate decahydrate (420 g) under ice-cooling, and mixed for 15 hours. The reaction solution was diluted with THF, the precipitate obtained by decantation was filtered off, and the solvent was distilled off under reduced pressure to obtain the title compound as pale yellow liquid (10 g, 95%).

1. temperaturecooling
2. temperatureThe reaction solution was refluxed for 3 hours, to the reaction solution
3. additionmixed for 15 hours
4. customthe precipitate obtained by decantation
5. filtrationwas filtered off
6. distillationthe solvent was distilled off under reduced pressure