tert-Butanol → Tert-butyl 2-(chlorosulfonyl)acetate

HRID 1162540Notes

Reaction equation

HRID 1162540 reaction equation
[C:1]([OH:5])([CH3:4])([CH3:3])[CH3:2].[Cl:6][S:7]([CH2:10][C:11](Cl)=[O:12])(=[O:9])=[O:8]>C1COCC1>[C:1]([O:5][C:11](=[O:12])[CH2:10][S:7]([Cl:6])(=[O:9])=[O:8])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6386tert-ButanolHCID 77642(Chlorosulphonyl)acetyl chloride

Product 1

HCID 43350783Tert-butyl 2-(chlorosulfonyl)acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of t-butanol (0.3 mL) in THF (3 mL) was added 2-chlorosulfonylacetyl chloride (0.1 mL, 1.0 mmol) at room temperature for 1 h. The volatiles were removed to provide the chlorosulfonyl-acetic acid tert-butyl ester (230 mg). The crude product was used without further purification.

Workup

  1. customThe volatiles were removed

Sources & evidence

ORD record
ord-d7bf5b9e1c9b41ac957732f8e4b4e51a
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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