HRID1162545

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID79177

Acetic acid, bromo-, 1,1-dimethylethyl ester

C6H11BrO2

结构：COc1ccc(OC)c(S(=O)(=O)Nc2nc(-c3ccc(C(C)C)cc3)cs2)c1

HCID59520368

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OC)c(S(=O)(=O)N(CC(=O)OC(C)(C)C)c2nc(-c3ccc(C(C)C)cc3)cs2)c1

HCID68648233

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

{(2,5-Dimethoxy-benzenesulfonyl)-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}-acetic acid tert-butyl ester was prepared following general procedure F using N-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-2,5-dimethoxy-benzenesulfonamide (126 mg, 0.3 mmol), tert-butyl bromoacetate (90.4 μL, 98%, 0.6 mmol), potassium carbonate (124 mg, 0.9 mmol) and DMF (1 mL). Purification (silica gel, ethyl acetate/hexanes 1:4) gave the product compound (111 mg, 0.208 mmol). LCMS m/z: 533 (M+1)+.

WORKUP

后处理

customPurification (silica gel, ethyl acetate/hexanes 1:4)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f7e7dbdec8f143c6add2041975b4b56a
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07820704B2
来源说明: uspto-grants-2010_10

反应 SMILES

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH:15][S:16]([C:19]3[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=3[O:27][CH3:28])(=[O:18])=[O:17])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Br[CH2:30][C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:34]([O:33][C:31](=[O:32])[CH2:30][N:15]([S:16]([C:19]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=1[O:27][CH3:28])(=[O:18])=[O:17])[C:12]1[S:13][CH:14]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[N:11]=1)([CH3:37])([CH3:36])[CH3:35]