Diethylamine → HCID 86601761, compound

HRID 1162551Notes

Reaction equation

[C:1]1(=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[C:8]([O:12][C:13](=[O:17])[CH2:14][CH2:15][NH2:16])([CH3:11])([CH3:10])[CH3:9].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C([N:49]=[C:50]=[S:51])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>>[C:8]([O:12][C:13](=[O:17])[CH2:14][CH2:15][N:16]([CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)[C:50]([NH2:49])=[S:51])([CH3:11])([CH3:10])[CH3:9]

Participants

Reactant 5

HCID 8021Diethylamine

HCID 8452Cyclopentanone

HCID 4154759Fmoc isothiocyanate

HCID 5049666Sodium triacetoxyborohydride

HCID 16218890Tert-butyl 3-aminopropanoate hydrochloride

Product 1

HCID 86601761HCID 86601761, compound

Procedure

3-(1-Cyclopentyl-thioureido)-propionic acid tert-butyl ester was prepared using general procedure D with cyclopentanone, beta-alanine tert-butyl ester hydrochloride, sodium triacetoxyborohydride, Fmoc isothiocyanate, and diethyl amine.

Sources & evidence

ORD record: ord-661fa220105644a7afc69e3a8d93c528
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820704B2

Reaction notes

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