反应详情

cis-4-Methyl-cyclohexanol (3.28 g, 28.7 mmol), NaH (1.09 g, 27.3 mmol, 60% suspension in mineral oil) and DMF (50 mL) were combined and sonicated as in general procedure L. The mixture was charged with 4′-fluoroacetophenone (2.18 mL, 17.8 mmol) and heated. After aqueous workup, the crude residue was purified on a silica gel column (gradient, hexane→2% EtOAc-hexane) to obtain 1-[4-(cis-4-Methyl-cyclohexyloxy)-phenyl]-ethanone (976 mg).

1. customsonicated as in general procedure L
2. temperatureheated
3. customAfter aqueous workup, the crude residue was purified on a silica gel column (gradient, hexane→2% EtOAc-hexane)