tert-Butyl bromoacetate → HCID 68647969, compound

HRID 1162565Notes

Reaction equation

HRID 1162565 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[C:14]([NH:16][CH2:17][C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)[CH:13]=[CH:12][N:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:23]([O:27][C:28](=[O:31])[CH2:29]Br)([CH3:26])([CH3:25])[CH3:24]>C1COCC1>[C:23]([O:27][C:28](=[O:31])[CH2:29][N:16]([C:14]1[CH:13]=[CH:12][N:11]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=2)[N:15]=1)[CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)([CH3:26])([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 68648279HCID 68648279, compound

Product 1

HCID 68647969HCID 68647969, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

{[2-(4-Isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl-amino}-acetic acid tert-butyl ester was prepared (149 mg) from [2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl-amine (135 mg, 0.44 mmol) and bromoacetic acid tert-butyl ester in THF by following the general procedure F. LCMS m/z: 425 (M+1)+.

Sources & evidence

ORD record
ord-e1f4118df3b348eab9ccbf728d2a646b
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

Loading…