Diethylamine → HCID 86079799, compound

HRID 1162596Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)=[O:4].C([N:31]=[C:32]=[S:33])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>>[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([C:32](=[S:33])[NH2:31])[N:6]=1)=[O:4]

Participants

Reactant 3

HCID 8021Diethylamine

HCID 657476methyl 1H-indazole-3-carboxylate

HCID 4154759Fmoc isothiocyanate

Product 1

HCID 86079799HCID 86079799, compound

Procedure

1-Thiocarbamoyl-1H-indazole-3-carboxylic acid methyl ester was prepared (113 mg) following general procedure D using 1H-Indazole-3-carboxylic acid methyl ester (120 mg, 0.69 mmol), Fmoc isothiocyanate (213 mg, 0.76 mmol), and diethyl amine (0.5 mL). LCMS m/z: 236 (M+1)+.

Sources & evidence

ORD record: ord-2528cafedf634f978fd6c539511c87c6
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820704B2

Reaction notes

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