HCID 68646448, compound → HCID 42643337, compound

HRID 1162621Notes

Reaction equation

HRID 1162621 reaction equation
Cl.[CH3:2][O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([NH:11][C:12]([C:14]2[S:15][C:16]([Cl:19])=[CH:17][CH:18]=2)=[O:13])[CH2:8][NH:7]1)=[O:5].BrC([C:25]1[CH:30]=[CH:29][C:28]([N:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]2=[O:37])=[CH:27][C:26]=1[F:38])C(N)=O>CN(C=O)C>[CH3:2][O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([NH:11][C:12]([C:14]2[S:15][C:16]([Cl:19])=[CH:17][CH:18]=2)=[O:13])[CH2:8][N:7]1[CH2:14][C:12](=[O:13])[NH:11][C:25]1[CH:30]=[CH:29][C:28]([N:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]2=[O:37])=[CH:27][C:26]=1[F:38])=[O:5]

Participants

4

Reactant 2

HCID 68646448HCID 68646448, compoundHCID 68646845HCID 68646845, compound

Product 1

HCID 42643337HCID 42643337, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

11.4 Using general procedure A with DMF as solvent (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-2-carboxylic acid methyl ester hydrochloride was reacted with 2-bromo-[2-fluoro-4-(2-oxo-pyridin-1-yl)-phenyl]-acetamide to give (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidine-2-carboxylic acid methyl ester. White solid. MS 533.2 ([M+H]+)

Sources & evidence

ORD record
ord-d539e006513944f38cc3d82c8d8e52f8
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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