HCID 68646448, compound → HCID 42643276, compound

HRID 1162651Notes

Reaction equation

HRID 1162651 reaction equation
Cl.[CH2:2]([O:4][C:5]([C@@H:7]1[C@@H:11]([NH:12][C:13]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[O:14])[CH2:10][NH:9][CH2:8]1)=[O:6])[CH3:3].BrC([C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]2=[O:38])=[CH:28][C:27]=1[F:39])C(N)=O>C1COCC1>[CH2:2]([O:4][C:5]([C@@H:7]1[C@@H:11]([NH:12][C:13]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[O:14])[CH2:10][N:9]([CH2:15][C:13](=[O:14])[NH:12][C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]3=[O:38])=[CH:28][C:27]=2[F:39])[CH2:8]1)=[O:6])[CH3:3]

Participants

4

Reactant 2

HCID 68646448HCID 68646448, compoundHCID 68647382HCID 68647382, compound

Product 1

HCID 42643276HCID 42643276, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

40.4 Using general procedure A with THF as solvent (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-3-carboxylic acid ethyl ester hydrochloride was reacted with 2-bromo-[2-fluoro-4-(2-oxopyridin-1-yl)-phenyl]-acetamide to give (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-methyl}-pyrrolidine-3-carboxylic acid ethyl ester. Light brown solid. MS 547.2 [M+H+].

Sources & evidence

ORD record
ord-18973684ffce49aeb34cc223bbc4a889
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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