6-Chloronicotinic acid → HCID 58748150, compound

HRID 1162671Notes

Reaction equation

HRID 1162671 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4]1.[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][N:17]=1>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][C@H:3]([CH2:2][NH:1][C:20]([C:19]2[CH:18]=[N:17][C:16]([Cl:15])=[CH:24][CH:23]=2)=[O:21])[CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 792226-Chloronicotinic acidHCID 1515152tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate

Product 1

HCID 58748150HCID 58748150, compound

Procedure

63.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 6-chloro-nicotinic acid to give (R)-3-{[(6-chloro-pyridine-3-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester. Yellow oil. MS 340.1 ([M+H]+)

Sources & evidence

ORD record
ord-6b52d91581bc4908870112cc8c3a13e4
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

Loading…