反应详情

温度

70 °C

2-(2-Bromoacetamido)-N-(2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (1.66 g, 4.60 mmol), 3-tert-butyl-1H-pyrazole-4-carbaldehyde (1.75 g, 11.49 mmol) and potassium carbonate (2.54 g, 18.38 mmol) were mixed with DMF (20 mL) and heated at 70° C. for 2 h. On cooling, the reaction was partitioned between EtOAc and water. The organics were washed with brine, dried over MgSO4 and concentrated directly onto silica for chromatographic purification (0-100% EtOAc/heptane). Concentration in vacuo yielded a white solid (1.64 g, 3.79 mmol, 83%).

1. temperatureOn cooling
2. customthe reaction was partitioned between EtOAc and water
3. washThe organics were washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated directly onto silica for chromatographic purification (0-100% EtOAc/heptane)
6. concentrationConcentration in vacuo