Hydrochloric Acid → HCID 178426306, compound

HRID 1163404Notes

Reaction equation

HRID 1163404 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:30]([C:31](=[O:42])[NH:32][C:33]3[CH:41]=[C:40]4[C:36]([CH:37]=[N:38][NH:39]4)=[CH:35][CH:34]=3)=[CH:29][C:17]3[N:18]=[C:19]([NH:21][C:22]4[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=4)[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[NH:39]1[C:40]2[C:36](=[CH:35][CH:34]=[C:33]([NH:32][C:31]([C:30]3[C:14]([N:11]4[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C:22]5[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=5)=[N:18][C:17]=4[CH:29]=3)=[O:42])[CH:41]=2)[CH:37]=[N:38]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178426307HCID 178426307, compound

Product 1

HCID 178426306HCID 178426306, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 157 was treated with 4M HCl in dioxane employing the procedure described for Example 156 to afford 6-(4-Aminopiperidin-1-yl)-2-(3-methylpyridin-2-ylamino)-1H-benzimidazole-5-carboxylic acid (1H-indazol-6-yl)-amide as a hydrochloride salt. MS: m/z 521 (M+H)+.

Sources & evidence

ORD record
ord-939a7a91b8bb4acd88321a10ef09664a
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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