Hydrochloric Acid → 1-(4-hydroxy-3,5-di-isopropylphenyl)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy]-ethanone

HRID 1163469Notes

Reaction equation

HRID 1163469 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([CH3:10])[CH2:6][C@H:5]1[OH:11])([CH3:3])[CH3:2].[OH-].[K+].Cl[CH2:15][C:16]([C:18]1[CH:23]=[C:22]([CH:24]([CH3:26])[CH3:25])[C:21]([OH:27])=[C:20]([CH:28]([CH3:30])[CH3:29])[CH:19]=1)=[O:17].Cl>CN1CCCC1=O>[OH:27][C:21]1[C:22]([CH:24]([CH3:26])[CH3:25])=[CH:23][C:18]([C:16](=[O:17])[CH2:15][O:11][C@@H:5]2[CH2:6][C@H:7]([CH3:10])[CH2:8][CH2:9][C@H:4]2[CH:1]([CH3:3])[CH3:2])=[CH:19][C:20]=1[CH:28]([CH3:30])[CH3:29]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 16666(-)-MentholHCID 858900592-Chloro-1-(4-hydroxy-3,5-di-isopropylphenyl)-ethanone

Product 1

HCID 577472331-(4-hydroxy-3,5-di-isopropylphenyl)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy]-ethanoneYield 34%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent2×

Procedure

To a solution of 15.63 g (100 mmol) of (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanol and 16.5 g (250 mmol) of potassium hydroxide in 100 ml of N-methylpyrrolidone a solution of 12.73 g (50 mmol) of 2-chloro-1-(4-hydroxy-3,5-di-isopropylphenyl)-ethanone in 400 ml of N-methylpyrrolidone is added dropwise at room temperature and under inert atmosphere. After the addition is completed stirring is continued for additional 16 hours. Then the reaction mixture is acidified with 1N HCl and extracted with ethyl acetate. The collected organic phases are washed with water and brine, dried and evaporated. Crystallization of the crude product from hexane gives 6.37 g of compound 110, m.p. 83-84° C.

Workup

  1. additionAfter the addition
  2. extractionextracted with ethyl acetate
  3. washThe collected organic phases are washed with water and brine
  4. customdried
  5. customevaporated
  6. customCrystallization of the crude product from hexane

Sources & evidence

ORD record
ord-5ef47b650d4440259010dfe17072ba60
Source dataset
uspto-grants-2010_10
Patent number
US07820865B2

Reaction notes

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