Hydrazine hydrate (1:1) → HCID 20438507, compound

HRID 1163867Notes

Reaction equation

HRID 1163867 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([O:13]CC)=O.O.[NH2:17][NH2:18]>>[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([NH:17][NH2:18])=[O:13]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12778914HCID 12778914, compound

Product 1

HCID 20438507HCID 20438507, compoundYield 77.5%

Procedure

2.08 g. of ethyl 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylate is added to 10 ml. of 98% by weight of hydrazine hydrate and the mixture is allowed to stand for 1 hour at room temperature and the obtained crystals are filtered and washed with water. 1.5 g. (77.5%) of 4-oxo-4,6,7,8-tetrahydro-pyrrolo(1,2-a)pyrimidine-3-carbohydrazide is obtained, melting at 180°-181° C.

Workup

  1. filtrationthe obtained crystals are filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-2c9ea199fd2b4ce1b9d36480cfc4655b
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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