p-Toluenesulfonic acid → HCID 13066707, compound

HRID 1164002Notes

Reaction equation

HRID 1164002 reaction equation
O[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([OH:19])=[O:18].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[Cl:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][C:7]1[C:2]2[O:19][C:17](=[O:18])[CH2:16][C:3]=2[CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 130666802-[2-Hydroxy-3-(2-chlorophenoxy)phenyl]acetic acid

Product 1

HCID 13066707HCID 13066707, compoundYield 67.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 2-[2-hydroxy-3-(2-chlorophenoxy)phenyl]acetic acid (1.9 g) and p-toluenesulfonic acid (0.5 g) in benzene 50 ml was treated in a similar manner to that of Example 1-(6), and the residue was recrystallized from a mixture of diethyl ether and n-hexane to give 7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-one (1.2 g). mp 118°-120° C.

Workup

  1. additionwas treated in a similar manner to that of Example 1-(6)
  2. customthe residue was recrystallized from a mixture of diethyl ether and n-hexane

Sources & evidence

ORD record
ord-69f008dfbfde476aa615417c08d405f0
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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