2-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetic acid → 2-[2-Hydroxy-3-(3-chlorophenoxy)phenyl]acetic acid

HRID 1164014Notes

Reaction equation

HRID 1164014 reaction equation
C[O:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:20])=[O:19]>C(OC(=O)C)(=O)C.I>[OH:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:20])=[O:19]

Participants

4

Reactant 1

HCID 205134882-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetic acid

Product 1

HCID 130666832-[2-Hydroxy-3-(3-chlorophenoxy)phenyl]acetic acidYield 48.3%

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolventHCID 24841Hydrogen iodideSolvent

Procedure

A solution of 2-[2-methoxy-3-(3-chlorophenoxy)phenyl]acetic acid (10 g) in acetic anhydride (30 ml) and 48% hydriodic acid (60 ml) were treated in a similar manner to that of Example 6-(6) to give 2-[2-hydroxy-3-(3-chlorophenoxy)phenyl]acetic acid (4.6 g). mp 99°-102° C.

Sources & evidence

ORD record
ord-ccd669f8e41a4e79a72dc8c290949f83
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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