Malonic Acid → HCID 54194699, compound

HRID 1164019Notes

Reaction equation

HRID 1164019 reaction equation
[CH3:1][O:2][C:3]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.C(O)(=O)[CH2:20][C:21]([OH:23])=[O:22].N1CCCCC1>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[CH:20][C:21]([OH:23])=[O:22]

Participants

5

Reactant 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 13066662HCID 13066662, compound

Product 1

HCID 54194699HCID 54194699, compoundYield 53.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Methoxy-3-(o-tolyloxy)benzaldehyde (28 g), malonic acid (24 g), pyridine (200 ml) and piperidine (2 ml) were treated in a similar manner to that of Example 4-(4), and the resultant crude product was crystallized with a mixture of benzene and n-hexane to give 3-[2-methoxy-3-(o-tolyloxy)phenyl]acrylic acid (17.5 g). mp 143°-146° C.

Workup

  1. customthe resultant crude product was crystallized with a mixture of benzene and n-hexane

Sources & evidence

ORD record
ord-7e6ef820848c470796bd66b812a89f43
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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