Ethyl Bromide → HCID 20513453, compound

HRID 1164036Notes

Reaction equation

[H-].[Na+].[C:3]([CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[C:12]=1[O:25][CH3:26])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4].[CH2:27](Br)[CH3:28]>>[C:3]([C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[C:12]=1[O:25][CH3:26])([CH2:27][CH3:28])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4]

Participants

Reactant 3

HCID 6332Ethyl Bromide

HCID 24758Sodium hydride

HCID 20513460HCID 20513460, compound

Product 1

HCID 20513453HCID 20513453, compoundYield 99%

Procedure

Sodium hydride (50%, 650 mg), ethyl 2-cyano-2-[2-methoxy-3-(o-tolyloxy)phenyl]acetate (4 g) and ethyl bromide (3.35 g) were treated in a similar, manner to that of Example 10-(5) to give oily ethyl 2-cyano-2-[2-methoxy-3-(o-tolyloxy)phenyl]butyrate (4.3 g).

Sources & evidence

ORD record: ord-a729089bbde1427c9d3fb12408252336
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04367238

Reaction notes

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