Sodium Iodide → HCID 20513432, compound

HRID 1164070Notes

Reaction equation

HRID 1164070 reaction equation
[C-:1]#[N:2].[K+].Cl[CH2:5][C:6]1[CH:7]=[C:8]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13].[I-].[Na+]>CS(C)=O>[CH3:13][O:12][C:11]1[CH:10]=[CH:9][C:8]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])=[CH:7][C:6]=1[CH2:5][C:1]#[N:2]

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 9032Potassium CyanideHCID 20513455HCID 20513455, compound

Product 1

HCID 20513432HCID 20513432, compoundYield 57.2%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Powdered potassium cyanide (2.05 g) was added to a solution of 2-chlorophenyl 3-chloromethyl-4-methoxyphenyl ether (8.5 g) and sodium iodide (4.7 g) in dimethyl sulfoxide (50 ml) at room temperature and stirred at the same temperature for an hour and then at 70° C. for 40 minutes. The reaction mixture was treated in a similar manner to that of Example 3-(7) to give oily 2-[2-methoxy-5-(2-chlorophenoxy)phenyl]acetonitrile (4.7 g).

Workup

  1. additionThe reaction mixture was treated in a similar manner to that of Example 3-(7)

Sources & evidence

ORD record
ord-ed0b74618b404884a5f41a4e2bb3db27
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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