1,4-Dibromobutane → HCID 13059826, compound

HRID 1164132Notes

Reaction equation

HRID 1164132 reaction equation
[Na].[CH2:2]([CH:5]1[S:9][C:8](=[O:10])[NH:7][C:6]1=[O:11])[CH2:3][CH3:4].[Br:12][CH2:13][CH2:14][CH2:15][CH2:16]Br>CN(C)C=O>[CH2:2]([CH:5]1[S:9][C:8](=[O:10])[N:7]([CH2:16][CH2:15][CH2:14][CH2:13][Br:12])[C:6]1=[O:11])[CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 5360545SodiumHCID 122200805-(Propyl)-2,4-thiazolidinedione

Product 1

HCID 13059826HCID 13059826, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

The sodium salt of 5-(propyl)-2,4-thiazolidinedione (1.59 g., 0.0088 mole) in 80 ml. of dry dimethylformamide is slowly added to 1,4-dibromobutane (5.68 g., 0.026 mole) in 20 ml. of dry dimethylformamide according to the procedure of Example 1(b) affords a 67% yield of 5-(propyl)-3-(4-bromobutyl)-2,4-thiazolidinedione, b.p. 117°-120° C. at 0.02 mmHg.

Sources & evidence

ORD record
ord-d9eae9facf0842328cc72e335cb777ff
Source dataset
uspto-grants-1983_01
Patent number
US04367335

Reaction notes

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