Tetrahydrofuran → HCID 12726273, compound

HRID 1164304Notes

Reaction equation

HRID 1164304 reaction equation
C([O:8][C:9]1[CH:22]=[CH:21][C:12]([C:13]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.O1CCCC1>[Pd].CO>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[O:14])=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 20511711HCID 20511711, compound

Product 1

HCID 12726273HCID 12726273, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.0 g. of 1-(p-benzyloxybenzoyl)-2-pyrrolidinone are hydrogenated in 20 ml. of absolute tetrahydrofuran and 20 ml. of absolute methanol over 300 mg. of palladium/carbon (5%) under atmospheric pressure and at room temperature. The catalyst is filtered off, the filtrate is concentrated and the residue is triturated with diethyl ether. After filtration, there is obtained 1-(p-hydroxybenzoyl)-2-pyrrolidinone, having a melting point of 179°-182° C.

Workup

  1. customat room temperature
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated
  4. customthe residue is triturated with diethyl ether
  5. filtrationAfter filtration

Sources & evidence

ORD record
ord-0e94fc9c62a64225856e93ff386f4b7b
Source dataset
uspto-grants-1983_01
Patent number
US04369139

Reaction notes

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