Chlorotrimethylsilane → HCID 54065593, compound

HRID 1164306Notes

Reaction equation

HRID 1164306 reaction equation
[C:1]([O:4][CH:5]1[CH2:9][C:8](=[O:10])[NH:7][CH2:6]1)(=[O:3])[CH3:2].[CH3:11][Si:12]([CH3:15])([CH3:14])Cl.O1CCCC1>C(N(CC)CC)C>[C:1]([O:4][CH:5]1[CH2:9][C:8](=[O:10])[N:7]([Si:12]([CH3:15])([CH3:14])[CH3:11])[CH2:6]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 1236559088877-55-8

Product 1

HCID 54065593HCID 54065593, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

10.0 g. of 5-oxo-3-pyrrolidinyl acetate and 8.82 ml. of trimethylchlorosilane are dissolved in 100 ml. of absolute tetrahydrofuran and then 9.65 ml. of triethylamine are added at -5° C. to 0° C. The temperature is held at -5° C. to 0° C. for 1 hour, the mixture is then filtered under an argon atmosphere, the filtrate is evaporated and the residue is distilled in vacuo. There is obtained 5-oxo-1-trimethylsilyl-3-pyrrolidinyl acetate, having a boiling point of 110° C./0.07 mmHg.

Workup

  1. filtrationthe mixture is then filtered under an argon atmosphere
  2. customthe filtrate is evaporated
  3. distillationthe residue is distilled in vacuo

Sources & evidence

ORD record
ord-6c0a6d7a8bb643ac88d3d1626abc487c
Source dataset
uspto-grants-1983_01
Patent number
US04369139

Reaction notes

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