Potassium Carbonate → Piperazine, 1-(2-ethylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride

HRID 1164477Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][Cl:7].[CH2:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH3:16].C([O-])([O-])=O.[K+].[K+]>>[ClH:7].[ClH:7].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][N:26]1[CH2:27][CH2:28][N:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[CH2:15][CH3:16])[CH2:24][CH2:25]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

HCID 27364601-(2-Ethylphenyl)piperazine

Product 1

HCID 3062135Piperazine, 1-(2-ethylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochlorideYield 76.5%

Procedure

8.3 g of 3,4,5-trimethoxybenzyl chloride and 3.8 g of N-(2-ethylphenyl)-piperazine and 3.5 g of K2CO3 are reacted and processed according to example 2. 6.5 g of N-(3,4,5-trimethoxy-benzyl)-N'-(2-ethylphenyl)-piperazine dihydrochloride is obtained.

Sources & evidence

ORD record: ord-72959b2f83ef4f92acb3676ba8878eb7
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04370329

Reaction notes

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