Potassium Carbonate → Piperazine, 1-(4-methoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride

HRID 1164483Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([O:27][CH3:28])[C:24]=1[O:25][CH3:26])[CH2:20][Cl:21].C([O-])([O-])=O.[K+].[K+]>>[ClH:21].[ClH:21].[CH3:28][O:27][C:23]1[CH:22]=[C:19]([CH:18]=[C:17]([O:16][CH3:15])[C:24]=1[O:25][CH3:26])[CH2:20][N:12]1[CH2:13][CH2:14][N:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

HCID 2697221-(4-Methoxyphenyl)piperazine

Product 1

HCID 3062144Piperazine, 1-(4-methoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochlorideYield 101.1%

Procedure

3.85 g of N-(4-methoxyphenyl)-piperazine, 4.33 g of 3,4,5-trimethoxybenzyl chloride and 3.5 g of K2CO3 are reacted and processed according to example 2. 4.5 g of N-(3,4,5-trimethoxy-benzyl)-N'-(4-methoxyphenyl)-piperazine dihydrochloride is obtained.

Sources & evidence

ORD record: ord-79cda333e2e64d4db2f74f68b5e233b8
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04370329

Reaction notes

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