Water → HCID 20511241, compound

HRID 1164485Notes

Reaction equation

HRID 1164485 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][Cl:7].[C:15]1([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O>CN(C)C=O>[ClH:7].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][N:24]1[CH2:25][CH2:26][N:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:22][CH2:23]1

Participants

5

Reactant 3

HCID 962WaterHCID 70961-PhenylpiperazineHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

Product 1

HCID 20511241HCID 20511241, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.32 g of 3,4,5-trimethoxybenzyl chloride and 3.24 g of N-phenyl piperazine is dissolved in 50 ml of dimethyl formamide in the presence of 3.0 g of water-free soda and is boiled for 8 hours under reflux. After sucking off insoluble matter, the filtrate is evaporated to dryness, the residue is dissolved in methanol. Subsequently hydrochloric acid gas is introduced in the solution and the precipitate sucked off. After drying, 3.4 g of N-(3,4,5-trimethoxybenzyl)-N'-phenyl-piperazine hydrochloride is obtained.

Workup

  1. temperatureunder reflux
  2. customthe filtrate is evaporated to dryness
  3. dissolutionthe residue is dissolved in methanol
  4. additionSubsequently hydrochloric acid gas is introduced in the solution
  5. customAfter drying

Sources & evidence

ORD record
ord-114546bcad824236a52dda5d8e2dd04e
Source dataset
uspto-grants-1983_01
Patent number
US04370329

Reaction notes

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