反应详情

A mixture of 350 g of crude N-[7-oxo(6-carboethoxy)octyl]phthalimide and 1000 ml of acetic acid, concentrated hydrochloric acid, and water was refluxed for three hours. The reaction mixture was stripped, the residue dissolved in methylene chloride and basified with 2 N NaOH solution. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and stripped to an orange oil, 73% pure by gc (SE-30, 90-280°@16°/min). This material was used without further purification in Preparation 3.

1. temperaturewas refluxed for three hours
2. customThe organic layer was separated
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. customstripped to an orange oil, 73% pure by gc (SE-30, 90-280°@16°/min)
6. customThis material was used without further purification in Preparation 3