反应详情

A mixture of 142.0 g (0.52 mole) of N-(7-oxooctyl)phthalimide, 60 ml of ethylene glycol, 5.80 g of p-toluenesulfonic acid and 290 ml of benzene was refluxed overnight using a Dean-Stark trap to collect the azeotrope. The reaction was cooled, treated with 2 N NaOH solution, the organic layer separated, dried over anhydrous potassium carbonate, filtered and stripped to give 125.25 g of orange oil, 76% pure by gc (SE-30, 90°-280°@16°/min).

1. temperaturewas refluxed overnight
2. customto collect the azeotrope
3. temperatureThe reaction was cooled
4. additiontreated with 2 N NaOH solution
5. customthe organic layer separated
6. dry with materialdried over anhydrous potassium carbonate
7. filtrationfiltered