Formaldehyde → HCID 12782916, compound

Anhydrous tetrahydrofuran (THF) (825 ml) and 49.5 g (0.49 mole) of diisopropylamine were added to a dry three-neck flask purged with nitrogen and maintained under a nitrogen atmosphere. After cooling the mixture to -20°, 300 ml of n-butyllithium in hexane (1.6 M) (0.49 mole) was added slowly to prevent the temperature from exceeding 0° and then 79.3 ml of anhydrous hexamethylphosphoramide (HMPA) (0.44 mole) was added. A solution of 51.28 g of palmitic acid (0.198 mole) in 400 ml of THF was added dropwise with stirring while maintaining the reaction temperature below 0°. A milky white suspension resulted after the addition of palmitic acid. The reaction mixture was brought to about 40° by using a warm water bath. The suspension changed to a clear solution as the temperature gradually reached 40°. This system was then connected to a formaldehyde generating system. Paraformaldehyde (40 g) was heated to a three-neck flask at 180°-200° to generate formaldehyde and the formaldehyde vapors were carried by a stream of nitrogen over the surface of the stirred solution of α-lithiated lithium palmitate prepared previously. The reaction was terminated after complete depolymerization of paraformaldehyde (2 to 21/2 hours). The reaction solution was cooled in an ice bath and neutralized with hydrochloric acid until acidic. The organic layer was separated and was concentrated under reduced pressure on a rotavac to remove most of the THF solvent. The resulting oily residue was dissolved in 2 liters of ether and was washed three times with 10% hydrochloric acid solution and then twice with water. The ether layer was dried over anhydrous Na2SO4 and the solvents were removed under reduced pressure to give 43.3 g (75%) of crude product, α-hydroxymethylpalmitic acid, which was recrystallized once from acetone to give 39.0 g (69% yield) of the product with m.p. 67°-71°, which was used without further purification in the next synthetic step.

1. custompurged with nitrogen
2. temperaturemaintained under a nitrogen atmosphere
3. temperatureAfter cooling the mixture to -20°
4. customfrom exceeding 0°
5. temperaturewhile maintaining the reaction temperature below 0°
6. customA milky white suspension resulted
7. customwas brought to about 40°
8. customchanged to a clear solution as the temperature gradually reached 40°
9. customprepared previously
10. customThe reaction was terminated after complete depolymerization of paraformaldehyde (2 to 21/2 hours)
11. temperatureThe reaction solution was cooled in an ice bath
12. customThe organic layer was separated
13. concentrationwas concentrated under reduced pressure on a rotavac
14. customto remove most of the THF solvent
15. dissolutionThe resulting oily residue was dissolved in 2 liters of ether
16. washwas washed three times with 10% hydrochloric acid solution
17. dry with materialThe ether layer was dried over anhydrous Na2SO4
18. customthe solvents were removed under reduced pressure
19. customto give 43.3 g (75%) of crude product, α-hydroxymethylpalmitic acid, which
20. customwas recrystallized once from acetone

ORD record

ord-77890ad9d8f04006b2bed3f6db07bf9f

Source dataset

uspto-grants-1983_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04370343