Toluene → HCID 19863364, compound

HRID 1164952Notes

Reaction equation

HRID 1164952 reaction equation
S(C1C=CC(C)=CC=1)([O-])(=O)=[O:2].[CH2:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[CH3:13].[H-].[Na+].[C:26]1([CH3:32])[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:12]([N:14]([CH2:32][CH:26]1[CH2:31][CH2:30][C:29](=[O:2])[CH2:28][CH2:27]1)[C:15]1[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=1)[CH3:13]

Participants

5

Reactant 4

HCID 1140TolueneHCID 19318N-Ethyl-p-nitroanilineHCID 24758Sodium hydrideHCID 85570p-Toluenesulfonate

Product 1

HCID 19863364HCID 19863364, compound

Procedure

In a manner similar to Preparation 23 react 4-(hydroxymethyl)cyclohexanone with p-toluenesulfonyl chloride in pyridine to obtain the tosylate. The tosylate is further reacted with N-ethyl-4-nitrobenzenamine and sodium hydride in toluene as in Preparation 12 to obtain the title compound.

Sources & evidence

ORD record
ord-a77059a32cbd41a2b2f49e7d96d1febf
Source dataset
uspto-grants-1990_03
Patent number
US04906634

Reaction notes

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